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Missense (171,172), nonsense (170), small deletions (173) and duplications (174) have already been identified leading to a variety of deleterious effects on the IGF1R including loss via nonsense mediated decay (174), production of a truncated protein (170), altered trafficking(171), reduced ligand binding (175) and altered tyrosine kinase activity (172)
Ela permite uma concentrao local elevada do peptdeo no local da leso
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Neuroendocrinol Lett
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