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doi: 10.1177/036354659502300320

Clinical symptoms result from binding of IgM to red cells in vascular beds where the temperature may fall below 30C, such as in exposed fingers, toes, and ears

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424 Moreover, the two components of the G3P shuttle (including GPD1 in the cytoplasm and GPD2 in the mitochondria) are up-regulated in mRNA and protein levels in diabetic islets, thus ensuring the transfer of electrons from NADH produced in glycolysis to mitochondria

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However, HIF activates the transcription of SOCS3 which inhibits JAK/STAT3 signaling and thus inhibits the expression of adiponectin (Fig