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Maldonado M, Chen J, Duan H, Huang T, Jiang G, Zhong Y (2021) High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction

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5-AMP-activated protein kinase (AMPK) can phosphorylate Nrf2 at the Ser558 residue in the nuclear transport signal, which is accompanied by a decrease in the stability of glycogen synthase kinase 3 (GSK-3) and results in Nrf2 translocation and ARE-related antioxidant gene expression [232]

In a case-control study involving 1260 patients with colon or rectum cancer and an equal number of controls, which was conducted as part of European Prospective Investigation into Cancer and Nutrition (EPIC), IGF-1 s relationship with the incidence of CRC was investigated