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They act as signaling molecules in the body, telling tissues and cells what to do

For instance, the heparin-binding domain of heparin-binding epidermal growth factor (HB-EGF) has been employed to enhance the retention of IGF-1 in cartilage in vivo , resulting in increased therapeutic efficacy in a rat medial meniscal tear model of OA

Heterozygous mutations in and around Sox9 can lead to campomelic dysplasia, a severe form of human chondrodysplasia that affects development of the skeleton, reproductive system, and face (Wagner et al., 1994)

Although there are various ways to immobilize microorganisms, and any method with a limitation for free-flowing of microorganisms can be used to produce and immobilize microorganisms, an ideal and universal application way for immobilizing microorganisms is still not available

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