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Examples of ototoxic drugs include certain antibiotics (eg, erythromycin [Erythrocin], clarithromycin [Biaxin], and azithromycin [Zithromax]), a number of chemotherapy drugs (eg, cisplatin [Platinol], carboplatin [Paraplatin], methotrexate [Otrexup], and vincristine [Oncovin]), loop diuretics (eg, furosemide [Lasix], bumetanide [Bumex], and ethacrynic acid [Edecrin]), acetaminophen (Tylenol), and non-steroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, ibuprofen [Advil], and naproxen [Aleve])

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Deglutathionylation is the process by which GSH moiety can be removed from proteinmixed disulfides, and it occurs when the environment becomes more reducing in an enzyme-dependent or -independent manner (Figure 1)

Omega-3 fatty acids and cognitive function

They also reported that the cytoprotective and ROS-reducing effects of ERW were abolished by degassing but not by neutralizing the pH, confirming that H 2 , not the pH or alkalinity, is responsible for the therapeutic effects of ERW [133]