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The highest levels of cytochrome P450 can be found in the endoplasmic reticulum of cells found in the liver and gastrointestinal tract, with the liver serving as the major site for phase I CYP metabolism

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10.1172/jci112364 25 BoenglerK.HilfikerkleinerD.DrexlerH.HeuschG.SchulzR
[3] Sekhar RV, Patel SG, Guthikonda AP, et al