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348 While SERMs regulate ER activity instead of inhibiting it, promising results have been observed with lasofoxifene, a new-generation non-steroidal SERMs

In the three 13-week, double-blind, global, phase 3 ALDAY clinical trials evaluating Mirogabalin for the treatment of pain associated with fibromyalgia, Mirogabalin did not meet the primary efficacy endpoint to demonstrate a statistically significant reduction in the weekly average of worst daily pain score from baseline to Week 13