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The selected subjects had a mean weight, as follows: Group I, 79.5017.9 kg

Hepatocytes were then pelleted by centrifugation at 50 g for 3 minutes and resuspended in 10 mL of DMEM

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Advanced disease models, including genetically stratified organoids, patient-derived iPSC lines, and age-appropriate 3D brain cultures, may offer more refined platforms to dissect these differences and identify compound-subtype associations (Sirkis et al., 2022)