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Additionally, the disease is characterized by brain atrophy, inflammation, oxidative damage, and disruption of the blood-brain barrier 2

However, the signal transduction involved in these processes has yet to be deciphered

Currently, arsenic trioxide is widely used to treat acute promyelocytic leukemia and various solid tumors through various mechanisms of action in clinical practice

While this route increases blood levels of glutathione, scientific evidence supporting its cosmetic benefits is limited and sometimes controversial

Mol Genet Metab 2002;77:189-93.PubMed 73