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Similarly, studies in rats revealed that ischemia/reperfusion destroys the structures of hemes b, c, and c 1 , and thereby the activity of complex III in cardiac cells [131]

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doi: 10.1111/j.1471-4159.2010.07109.x

Figure 1 2 The cardiac macrophage landscape in sepsis 2.1 Origin and heterogeneity of cardiac macrophages The heart harbors a diverse population of macrophages originating from two primary lineages: embryo-derived resident macrophages and monocyte-derived macrophages recruited from the circulation ( - populations) self-renew and help maintain tissue homeostasis, whereas circulating monocytes (e.g., CCR2 + populations) are recruited in response to injury or inflammation ( Figure 2 )