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Since glutathione is the main component in detoxification of hydroperoxides in mitochondria, its depletion in the brain is believed to promote mitochondrial insult most likely via increased ROS

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Uhl W, Buchler MW, Malfertheiner P, et al

The growing popularity parallels to cigarettes and links to respiratory damage and disease associated with e-cigarettes all highlight the concerns surrounding their use in current society
