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doi: 10.1097/ADM.0000000000000443 119 MarikP

The development of small and large mammalian models of exogenous and endogenous acrolein exposures, both acute and chronic, will promote detailed mechanistic investigations and toxicity studies

IGF-1 and its receptor IGF-1R are involved in these critical pathways and therefore play a pivotal role in healthy tissue homeostasis but also a far less desirable role in diseases such as cancer where they can be responsible for the survival and proliferation of malignant cells

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10.1016/j.jff.2016.03.028 23 ChenY