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Mutant p53-associated molecular mechanisms of ros regulation in cancer cells
In melanoma studies, ubiquitin specific peptidase 22 controls melanoma metastasis and sensitivity to ferroptosis through the SIRT1/phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphoinositol-3 kinase (PI3K) signaling pathway, suggesting that activation of the SIRT1 pathway may enhance melanoma cells sensitivity to ferroptosis (Sun et al., 2024)
In fact, many studies on natural products as potential therapy approaches against APAP hepatotoxicity were due to their enhancement effects on phase II metabolic enzymes and/or inhibitory effects on cytochrome P450 enzymes [125], [130], [17],]

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Pharmacology , 68 (2), 105114

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