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In cultured animal cells, ASC can enhance 5-hydroxymethylcytosine (5hmC) generation as a cofactor for ten-eleven-translocation (TET) dioxygenase, a type of 2-ODD, which catalyzes the oxidation of 5-methylcytosine (5mC) into 5hmC (Dickson et al., 2013

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These models provide more biological context than isolated cell culture, but they remain preclinical systems

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For example, it has been shown that glutathione is decreased due to an inability to produce glutathione in the extracellular lung fluid of children with chronic asthma [45] and in the macrophages of adults with human immunodeficiency virus (HIV) [46]