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So that we could understand the mechanisms regulating granuloma formation in sarcoidosis, scRNA-Seq was performed on lesional skin samples from 3 patients with sarcoidosis and 5 healthy subjects (Supplemental Table 1

32,153 The mucociliary clearance function relies heavily on the mucosal pH

This activated HIF-1 further stimulates the PA-1 expression, induces ECM accumulation, and leads to OSF (Tsai et al., 2015)

Biochemistry 40 , 1288612895 (2001)

Shima S, Netrusov A, Sordel M, Wicke M, Hartmann CG, Thauer KR

Importantly, several studies have showed that inhibiting SLC7A11 activities suppresses glutamine-derived glutamate export, enhance glutamate to replenish the TCA cycle intermediates, and promote ROS production [63, 71, 72], suggesting that SLC7A11 antagonizes pro-ferroptotic glutaminolysis and that increasing glutamine metabolism under blockage of GSH synthesis upregulates ROS levels and promotes ferroptosis, which may provide a novel treatment guideline option for ferroptosis-based tumor therapy
