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Following its synthesis, it is secreted to be taken up by HSPG and stored in lysosomes [ A ) than Hpa L [ In vitro studies using EC established that acute incubation of these cells with high glucose had a robust influence on Hpa secretion [ L secretion being greater than Hpa A [ A , its heparan sulfate hydrolyzing ability would be capable of releasing myocyte surface-bound proteins including LPL