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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

If low or low-normal, use higher dose supplementation or injectable b12

For example: Epoxides undergo an acid-catalyzed ring-opening reaction with water (a hydrolysis) to give the corresponding 1,2-dialcohol, or diol , also called a glycol

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Human lumbar vertebrae are required to withstand pressure from more than 50% of the body weight that is further influenced by our upright posture, whereas the spine of quadrupeds, of which most models are based on, does not bear such vertical pressure in the resting state

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