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By now, there are a few studies on the pharmacokinetics and bioavailability of intranasal lamotrigine in rats and mice, showing promising results with high brain-targeting efficacy [247, 248], but further research has to be done especially regarding efficacy

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In contrast, when histamine is released during the digestive process, binding to the H2 receptor stimulates a different GPCR-mediated cell signaling pathway that results in release of HCl into the gastric lumen

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