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Furthermore, research using models where anthraquinones like emodin (EMO) themselves induce injury has revealed how protective flavonoids such as isoliquiritigenin work by upregulating cellular detoxification and antioxidant defenses via the Nrf2/Keap1 pathway, showcasing the models utility in studying herb-herb interactions or intrinsic toxicity mitigation (Ni et al., 2022)

doi: 10.1016/j.celrep.2019.05.019 73 ArmstrongAWWuJJohnsonMAGrapovDAziziBDhillonJet al

(2020) 28:13446.e4

In rat fibroblasts and epithelial cells, valproic acid inhibits TGF-1-stimulated -SMA expression and induces autophagy, thereby treating RF [108]

During the immunofluorescence imaging of GFAP-stained brain sections, entire coronal sections were evaluated for reactive astrocytes

J Drug Delivery Sci Technology