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In the SURPASS-2 head-to-head trial: tirzepatide 15 mg achieved mean HbA1c reduction of 2.30% vs semaglutide 1 mg at 1.86%

"Most interesting is the fact that it seemed to take over two years to muster enough concern for patient safety that they think this molecule ought to be placed off limits," says Brunner, who heads the compounding pharmacist trade group

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GLP-1 is synthesized by the pre-proglucagon peptide encoded by the GCG gene in entero-endocrine L cells in the small and large intestine [22, 23]

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