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Keap-1 not only binds Nrf2 to cytoplasmic actin filaments in the basal state but it also acts as a sensor, especially of subtle redox changes in the cell

A significant amount of research has indicated that individuals with anaemia frequently experience osteoporosis as well (125, 126), which may be related to iron overload-mediated ferroptosis caused by long-term blood transfusions in anaemia patients (127), and their fracture risk is associated with the frequency of blood transfusions (128)

35 Maximal binding occurs if the column is fully reduced

This effect was rapidly reversible upon washout, absent in 5-HT 2A knockout (KO) mice, and blocked by ketanserin or ifenprodil, a selective antagonist of NMDARs containing GluN2B subunit

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doi: 10.3920/BM2020.0057 [DOI] [PubMed] [Google Scholar] 84.Deleu S, Machiels K, Raes J, Verbeke K, Vermeire S