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Published literature suggests that IGF-1R activation by IGF-1 induces translocation of the transient receptor potential vanilloid 2 (TRPV2) channel to the cell membrane 43

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This destroys the cell/mitochondrial redox balance and accelerates cell death through iron-mediated lipid peroxidation, providing a promising chemotherapy strategy for peritoneal metastases of epithelial ovarian cancer

ejection fraction of left ventricle (EF LV) (%) = stroke volume (mL)/DV (mL) 100 (in healthy animals, DV 0.16 0.03, SV 0.013 0.002, EF LV 90 4)

Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress