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This reflects a key implication in malignancies, whose intrinsic environment is highly dependent on glycolysis, as characterized by the Warburg effect

10.1111/j.2042-7158.2012.01594.x 173 PerrinL.Loizides-MangoldU.SkarupelovaS.PulimenoP.ChanonS.RobertM.et al (2015)

Diets high in 6 polyunsaturated fatty acids (e.g., linoleic and arachidonic acid found in oils) enrich adipocyte membranes with precursors for pro-inflammatory eicosanoids (for instance, PGE 2 from arachidonate), which yield signals activating ERK/PI3K pathways 364

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This would mean that each SC sequesters its own subpopulation of the mobile electron carriers (CoQ and/or cytochrome c ) and electron transfer between two sequential enzymes (CI-CIII and CIII-CIV) occurs by successive reduction and reoxidation of the mobile intermediates that are enclosed in internal channels connecting one enzyme active site to another (50, 61)