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Although proper iron metabolism is required for the physiological process in oligodendrocytes, aberrant iron homeostasis under pathological situations may exacerbate oxidative stress in oligodendrocyte linage cells and lead to cell damage [59, 62]

PMID 25766143

In addition, a substrate-based clustering is also observed by the neighbour joining of enzymes from the same gene clusters (Alp1S with Alp1V, and Lom16 with Lom17)

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