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Biosci Biotechnol Biochem 58(5):878880 Koontz L (2014) TCA precipitation

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Large molecules, such as lactulose, are thought to traverse the epithelium by paracellular pathways

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Peripherally, PNIs result in the immediate loss of both motor and sensory function distal to the injury, Wallerian degeneration of the distal nerve segment, neuromuscular junction denervation and degradation, and muscle atrophy (Brushart, 2011)