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Cyclin-dependent kinases regulate the antiproliferative function of Smads

Humans with -glutamyl transpeptidase deficiency have been reported, and these individuals display increased glutathione concentration in urine (glutathionuria) and in blood plasma, and some display central nervous system abnormalities

However, stacking increases complexity

Drge and Breitkreutz, 2000

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Large conformational changes in the catalytic cycle of glutathione synthase