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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIVassociated lipodystrophy, not as a general weightloss drug for the wider population. Tesamorelin Risks and Considerations Like all hormonemodulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injectionsite reactions, and effects on glucose metabolism in susceptible patients
Elevates NAD+ and S-adenosylmethionine (SAM) levels, shifting metabolic flux toward energy expenditure and away from fat storage 1-4
It is also needed for healthy red blood cell formation and for the development and function of the central nervous system (brain, spinal cord, and nerves)
Although it isnt FDA-approved for general weight loss, some people use it off-label
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Some manufacturers recommend taking supplements with food primarily to reduce potential stomach upset rather than to enhance absorption
