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The Ras/MAPK cascades catalyze the phosphorylation of cytoplasmic substrates or nuclear transcription factors, mediating mitogenic effects and committing the cell to either a proliferative or differentiation cycle [199]

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The opposite of this mechanism is the heterolytic fission in which, after a covalent break, one atom receives both electrons (this gives a negative charge) while the other remains with a positive charge.Lipid peroxidation leads to the breakdown of lipids and to the formation of a wide array of primary oxidation products such as conju- dienes or lipid hydroperoxides, and secondary products including MDA, F2-isoprostane or expired pentane, ethane or hexane

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The remaining supernatant was heated at 70 C for 10 min

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