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First-in-human trial of the PI3K-selective inhibitor SAR260301 in patients with advanced solid tumors

All compounds (letrozole, BTN, and Met) were administered orally via gavage

In the ever-accelerating realm of longevity research, discerning the most impactful compounds and their optimal application is crucial

Its primary research significance lies in its capacity to activate the enzyme telomerase (specifically the catalytic subunit hTERT) and modulate chromatin structure

doi: 10.1038/ng0793-289

Its anti-inflammatory effect includes decreasing levels of inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), making it a potential anti-inflammatory agent