glutathione metabolism and its role in hepatotoxicity Frontiers Glutathione disulfide sensitizes hepatocytes to

C.S.R.S

Class III FINs such as FIN56 act by indirect inhibiting and inactivating GPX4 via the squalene synthase-mevalonate pathway, which participates in the mitochondrial electron transport chain and also functions as endogenous lipophilic antioxidants [40, 108]

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However, chronic alcohol exposure has been shown to significantly reduce BDNF levels in various brain regions, including the hippocampus and prefrontal cortex, which are critical for mood regulation

Similar human studies on other heavy metals have been also reported [36]