s acetyl glutathione wikipedia Research supports significantly higher intracellular glutathione levels with acetylated forms compared to standard reduced glutathione The Science Behind S-Acetyl Glutathione

In the previous study, teicoplanin (TIL) treatment significantly upregulated the relative hepatic expression of HSP70 and NF-B mRNAs and blocked Nrf2/HO-1 mediated responses, indicating that TIL could induce oxidative stress and hepatotoxicity by blocking Nrf2 mediated defense responses and increasing NF-B signaling pathways

There are a few more factors that depend on what your goals for treatment

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The SOCS1-mimicking peptide reduced lupus-like symptoms in mouse models, demonstrating the potential to regulate an immune response that runs on overdrive

Kidney dysfunction may reduce B12 clearance and increase levels

Leuk Res 33(5):638644 Kusaka M et al (1991) Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent