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Several guidelines 7,8,9 , including the American Diabetes Association (ADA), recommend metformin as the first-line hypoglycemic agent for patients with T2DM or DKD

Paterson BM, Donnelly PS (2011) Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

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Confirmation by in vivo biochemical findings

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Future studies should integrate single-cell spatiotemporal omics, optogenetic modulation, and organoid models to systematically elucidate the hierarchical architecture of exercise-activated cardioprotective networks, thereby establishing theoretical foundations for personalized cardiac rehabilitation strategies