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These observations underscore the involvement of the hypoxic microenvironment in MS-associated vascular pathology, implying that strategies aimed at improving vascular oxygenation, mitigating immunoinflammatory damage, downregulating vasoactive substances, and reversing vascular abnormalities may reduce ischemic damage to the skin and visceral organs
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As detailed by Chang and colleagues, taurine reduced the inhibition of Ca 2+ uptake induced by Hcy (0.5 mM) in rat mitochondria
