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Accordingly, microbiota-targeted interventions have emerged as promising approaches to restore immune homeostasis and improve clinical outcomes

In -cells, glutamate potentiates glucose and incretin-stimulated insulin signaling and islet survival via NMDA receptors (139)

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Although these mice have normal CoQ levels in most of the tissues, they show a reduced level of MCLK1 protein (approximately 2-fold), reduced ROS levels, decreased oxidative stress and decreased oxidative damage, and their life span is 1530% longer than wild-type mice [137,139,140]

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