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[DOI] [PMC free article] [PubMed] [Google Scholar] 320.Sangwung, P., Petersen, K

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Using immunofluorescence and confocal microscopy, we observed prominent mitochondrial but minimal nuclear localization of catalytic subunit of the pyruvate dehydrogenase complex (PDHe1) (Supplemental Figure 6A)

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In obese subjects, overpopulated immune cells (mainly macrophages) and dysfunctional adipocytes secrete a variety of cytokines and chemokines, causing low-grade long-term inflammation in AT, which plays a determining role in metabolic diseases, such as cardiovascular diseases, liver steatosis and type 2 diabetes [2]