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Lipoprotein particles are internalized by astrocytes through endocytosis, leading to the release of FFAs and their incorporation into LDs, thereby mitigating the detrimental effects of FFAs [141]

In particular, there is evidence to suggest that plasmalogens could protect unsaturated membrane lipids from oxidation by singlet oxygen (Broniec et al., 2011)

Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation 15,19

8 A melanotic macule, by contrast, is typically well-defined, uniform in color, stable in size, and flat

Specifically, the human -hydroxylase enzymes are members of the CYP4A and CYP4F families that preferentially hydroxylate the terminal methyl group of C10C26 length fatty acids