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Renal Cell Carcinoma (RCC) CGA (IC 50 40 M) selectively suppresses cell proliferation and colony formation of human RCC A498 cells but without effects on human embryonic kidney (HEK293) cells through upregulation of cleaved levels of caspase-3, caspase-9, and PARP and the ratio of Bax/Bcl-2 and inhibition of the PI3K/Akt/mTOR pathway [301]