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Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus

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Before LCMS analysis, the dried extracts were reconstituted in 100 L of ACN:H 2 O (1:1, v/v), sonicated for 10 min, and centrifuged for 15 min at 16,200 g and 4 C to remove insoluble debris

This study provides direct evidence that ALA plays a specific role in the antioxidant system against oxidative stress, and strongly suggests a therapeutic role of ALA in cisplatin-induced ototoxicity as a GSSG reductant
