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"Cuanta ms dosis se toma, menos se absorbe" En dosis bajas o moderadas, tambin llamadas fisiolgicas, que son las que aportaramos a travs de la alimentacin, (aunque podramos meter aqu tambin la B12 aportada por alimentos fortificados, o suplementacin en cantidades muy pequeas), la absorcin depende del factor intrnseco secretado y de los receptores intestinales del complejo de Castle, que son quienes regularn la absorcin

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Beyond direct modulation of neuronal activity, SCFAs influence neuroepithelial signaling through actions on enteroendocrine cells, which express multiple G protein-coupled receptors (GPCRs), including free fatty acid receptors 2 (FFAR2) and FFAR3 (also known as GPR41), enabling SCFA-driven hormone and neuropeptide release