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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) (Kalsi et al., 2011

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(1995) The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation

Vitamin C promotes the conversion of cholesterol into bile acid by participating in the microsomal respiratory chain ( 3 Folate in hepatic lipid metabolism 3.1 Hepatic lipid metabolism Hepatic lipid metabolism mainly includes de novo synthesis of fatty acids using acetyl-CoA as raw materials, fatty acid uptake, very low density lipoprotein (VLDL) secretion, and fatty acid oxidation ( Fatty acid oxidation is the primary process of hepatic lipid metabolism, by which fatty acids break down into CO 2 and H 2 O, releasing large amounts of ATP
