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Mitochondrial dysfunction can result in intracellular lipid accumulation, leading to lipid toxicity, lipid peroxidation, and a series of pathological processes that ultimately cause further mitochondrial fragmentation, dysfunction, and even cell death [47, 48]

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doi: 10.1016/j.dci.2004.06.001

Meanwhile, the outer membrane will rupture, and proteins, such as cytochrome c and apoptosis-inducing factor (AIF), will be released from the intermembrane space into the cytosol, triggering apoptosis [190, 191]

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