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Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice

They operate on entirely separate biological pathways

Additionally, PH may confer potent insulinotropic effects, allowing the permissive effects of insulin on muscle protein synthesis (MPS) [186]

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Activation of the PI3K-Akt pathway enhances the activity of Gli-1, a key metabolite of the Hedgehog pathway, suggesting an interaction between the two in the inflammatory response

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