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Pretreatment with FG-4592 was found to attenuate folic acid-induced renal ferroptosis via a mechanism involving NRF2 activation [101]

Our in vitro data indicate that the biophysical characteristics of PSR-1 condensates can be influenced by oxidative states: H 2 O 2 prompted a transition of PSR-1 condensates from dispersed droplets and aggregates to clustered aggregates, whereas DTT diminished PSR-1 condensates

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Much of this iron is directed to the electron transport chain, including forming ironsulfur (FeS) clusters and heme groups embedded in respiratory complexes IIV