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Seek urgent medical attention if you experience: Persistent high blood glucose readings (consistently above 15 mmol/L) Blood ketones above 1.5 mmol/L (check ketones if you're unwell or if glucose is persistently above 13.9 mmol/L) Signs of hyperosmolar hyperglycaemic state (extreme thirst, frequent urination, confusion, drowsiness) Severe abdominal pain or persistent vomiting Signs of pancreatitis (severe upper abdominal pain radiating to the back) Your GP can arrange appropriate monitoring, adjust your treatment regimen, and provide ongoing support to ensure your diabetes remains well-managed whether you continue or discontinue Rybelsus

doi: 10.1007/s00125-015-3795-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 27

It signals fullness through GLP-1 receptors in the hypothalamus and brainstem, which patients describe as the quieting of food noise, connected to the psychology around overeating and resultant weight gain

As well as stimulating insulin release, GLP-1R agonists promote satiety and reduce food intake, leading to weight loss

Consider testing for ketones if you are unwell or have persistently high glucose

momentum further picked up in Q4, said Elara Capital