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[Google Scholar] [191].Malmsten C, Lignell A

Case reports of acute contact dermatitis and systematic reactions to NS have been documented

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153 Noise can damage cochlear tissues through a variety of mechanisms that are also factors in age-related hearing loss, such as increased inflammation and free radical production, disordered calcium metabolism in the inner ear, altered cell signaling, and programmed cell death, all of which have been implicated in hair cell and auditory neuron damage

For example, vitamin D induces BDNF release via calcium signaling by upregulating voltage-gated calcium channels, while folate and B vitamins are involved in neuroprotective effects through limiting neurotoxic homocysteine levels, which inhibits neurotrophic signaling [221]

Characterize off-target effects through selectivity profiling against related receptor subtypes