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They are also often perceived as simpler to operate and maintain compared to closed systems like photobioreactors, with tasks like mixing, nutrient addition, and harvesting being less technically demanding

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Its overexpression in HIF-1-deficient intestinal epithelial cells leads to restoration of barrier function, confirming a crucial link between HIF and TJ function in the intestine (Saeedi et al., 2015)

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Although the retro-inverso approach may fail to accurately reproduce biological function in the context of helical structures (e.g., p53 or HIV-1 proteins), certain exceptionssuch as the binding of a p53-derived retro-inverso peptide to its regulator MDM2demonstrate that well-designed D-peptides can, in specific cases, effectively mimic the function of the original peptide