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10.1161/CIRCULATIONAHA.107.727347 107

Bisphosphonates promote the expression of the osteogenic genes alkaline phosphatase (ALP) , bone morphogenetic protein-2 (BMP-2) and osteocalcin (OC) in marrow mesenchymal stem cells (MSCs) (Ribeiro et al., 2014) and directly enhance osteoblast formation and subsequent mineral deposition, which may be another mechanism by which they exert anti-osteoporosis (Lindtner et al., 2014)

pediatric and intranasal regimens are detailed in specialized dosing references and should be individualized

TB-500 has been studied for its effects on muscle recovery, joint health, and inflammation