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Specific gut hormones, such as glucagon-like peptide 1 (GLP-1) are released in response to ingestion and regulate food intake both in animals and humans by influencing specific appetite-regulating circuits in the brain

There may be unmeasured confounding factors such as lifestyle, other medications, psychological stress, or health-seeking behavior differences between the groups

doi: 10.1007/978-3-031-63657-8_7

Similarly, high-dose liraglutide, when combined with caloric restriction and increased physical activity, has been shown to reduce both visceral fat and liver fat content, as measured by MRI and proton magnetic resonance spectroscopy ( 1 H-MRS), respectively, compared with placebo with lifestyle intervention alone in individuals with overweight or obesity at high ASCVD risk