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Similarly, in HD, one of the many explanations that have been put forth refers back to mitochondria, proposing that medium spiny neurons, known for having very high energy demands, are particularly vulnerable to mitochondrial malfunction and respiration suppression caused by mutant Huntingtin [46]

The descending pain pathway consists of midbrain and brainstem regions that project to the dorsal horn of the spinal cord and modulate pain signals, either enhancing or inhibiting pain [10]