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Remarkably, most normal individuals harbor small numbers of bone marrow cells with PIGA mutations identical to those that cause PNH

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The efficacy of canagliflozin in diabetes subgroups stratified by data-driven clustering or a supervised machine learning method: a post hoc analysis of canagliflozin clinical trial data

10.1161/01.res.80.1.45 112 FultonD.GrattonJ

During reticulocyte maturation, lipid peroxidation mediated by 15-lipoxygenase in humans and rabbits and by 12/15-lipoxygenase (ALOX15) in mice was considered the initiating event for the elimination of mitochondria but is now known to occur through mitophagy

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